Acute adriamycin-induced cardiotoxicity is exacerbated by angiotension II
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چکیده
منابع مشابه
Abrogation of adriamycin-induced cardiotoxicity by selenium in rabbits.
Adriamycin-induced cardiomyopathy in rabbits was produced by intravenous injections of the drug with a short therapeutic schedule (3 mg/kg body wt administered as four intermittent doses). Animals receiving selenium supplementation of Adriamycin showed preservation of the normal pattern of the heart histologic picture. The protective effect of selenium was accompanied by increased selenium leve...
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Adriamycin, a widely used anthracycline antibiotic in multiple chemotherapy regimens, has been challenged by the cardiotoxicity leading to fatal congestive heart failure in the worst condition. The present study demonstrated that Dihydromyricetin, a natural product extracted from ampelopsis grossedentat, exerted cardioprotective effect against the injury in Adriamycin-administrated ICR mice. Di...
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BACKGROUND Adriamycin (ADR) is an effective chemotherapeutic agent against cancers but its clinical use is limited due to its cardiotoxicity. It has been suggested that the pathogenesis involves inhibition of nucleic acid and protein synthesis, free radical formation and lipid peroxidation. Schisandra (SC) has strong antioxidant activity. We investigate the protective effects of SC on adriamyci...
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Free oxygen radicals and lipid peroxidation are responsible for adriamycin-induced cardiotoxicity. Amifostine is a scavenger of free radicals and may function as a selective cytoprotective agent. The aim of this study was to investigate the effects of amifostine on adriamycin-induced lipid peroxidation and the levels of protective enzymes in the heart. Male Wistar rats were randomly allocated t...
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The pharmacological and therapeutic effects of Adriamycin entrapped in positively charged and negatively charged lipo somes were compared with those of free Adriamycin in mice. Liposomes were composed of phosphatidylcholine and choles terol mixed with stearyl amine (positive charge) or phosphatidylserine (negative charge). Positive liposomes with entrapped Adriamycin effectively retarded the in...
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ژورنال
عنوان ژورنال: Cytotechnology
سال: 2014
ISSN: 0920-9069,1573-0778
DOI: 10.1007/s10616-014-9748-6